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Chronic low-grade inflammation further induces persistent microglial activation and polarization shifts, BBB endothelial dysfunction, and mitochondrial energy metabolism abnormalities, exacerbating neuronal damage [30]

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These substances are administered in small amounts(1-3cc)

Each 10 mL multi-dose vial contains 100 mcg/mL of Vitamin B12, equivalent to ten 1 mL weekly injections, making it a convenient and cost-effective option for patients requiring regular supplementation

Understanding the dose-response relationship is essential for designing appropriate research protocols [9]

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